(±) -Ibipinabant (Standard)
(±) -Ibipinabant (Standard) is the analytical standard of (±) -Ibipinabant. This product is intended for research and analytical applications. (±) -Ibipinabant ((±) -SLV319) is the racemate of SLV319. (±) -Ibipinabant ((±) -SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
Product Specifications
CAS Number
362519-49-1
UNSPSC
12352100
Target
Cannabinoid Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Metabolic Disease
Smiles
C/N=C(N1N=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)C1)\NS(=O)(C4=CC=C(Cl)C=C4)=O
Molecular Formula
C23H20Cl2N4O2S
Molecular Weight
487.40
References & Citations
[1]Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22 (19) :6173-80.|[2]Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB (1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47 (3) :627-43.|[3]Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14 (6) :555-64.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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