Favipiravir-13C15N
Favipiravir-13C15N (T-705-13C15N) is 13C and 15N labeled Favipiravir. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP) . Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
Product Specifications
Product Name Alternative
T-705-13C15N
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis; Influenza Virus; Isotope-Labeled Compounds; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=[13C]([15NH2])C1=NC(F)=CNC1=O
Molecular Formula
C4 13CH4FN2 15NO2
Molecular Weight
159.09
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Furuta Y, et al. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 2013 Nov;100 (2) :446-54.|[3]Rocha-Pereira J, et al. Favipiravir (T-705) inhibits in vitro norovirus replication.
 Biochem Biophys Res Commun. 2012 Aug 10;424 (4) :777-80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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