Elvitegravir-13C6

Elvitegravir-13C6 (GS-9137-13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

Product Specifications

Product Name Alternative

GS-9137-13C6; JTK-303-13C6; D06677-13C6

UNSPSC

12352005

Target

HIV; HIV Integrase; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(O)C1=CN(C2=C(C1=O)C=C(C(OC)=C2)C[13C]3=[13C][13C]=[13C][13C](Cl)=[13C]3F)[C@@H](C(C)C)CO

Molecular Formula

C17 13C6H20ClFNO5

Molecular Weight

450.82

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Shimura K, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137) . J Virol. 2008 Jan;82 (2) :764-74.