RO4987655 (Standard)

RO4987655 (Standard) is the analytical standard of RO4987655. This product is intended for research and analytical applications. RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.

Product Specifications

CAS Number

[874101-00-5]

UNSPSC

12352100

Target

MEK; Reference Standards

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

FC(C(F)=C(NC1=CC=C(I)C=C1F)C(C(NOCCO)=O)=C2)=C2CN3C(CCCO3)=O

Molecular Formula

C20H19F3IN3O5

Molecular Weight

565.28

References & Citations

[1]Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15 (23) :7368-74.|[2]Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [ (18) F] FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4 (1) :34.