RO4987655 (Standard)
RO4987655 (Standard) is the analytical standard of RO4987655. This product is intended for research and analytical applications. RO4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2.
Product Specifications
CAS Number
874101-00-5
UNSPSC
12352100
Target
MEK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
FC(C(F)=C(NC1=CC=C(I)C=C1F)C(C(NOCCO)=O)=C2)=C2CN3C(CCCO3)=O
Molecular Formula
C20H19F3IN3O5
Molecular Weight
565.28
References & Citations
[1]Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15 (23) :7368-74.|[2]Tegnebratt T, et al. Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [ (18) F] FDG-PET imaging combined with proteomic approaches. EJNMMI Res. 2014 Dec;4 (1) :34.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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