Refametinib (Standard)

Refametinib (Standard) is the analytical standard of Refametinib. This product is intended for research and analytical applications. Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor with IC50s of 19 nM and 47 nM, respectively.

Product Specifications

CAS Number

[923032-37-5]

UNSPSC

12352100

Target

MEK; Reference Standards

Related Pathways

MAPK/ERK Pathway; Others

Field of Research

Cancer

Smiles

O=S(C1(C[C@H](O)CO)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O

Molecular Formula

C19H20F3IN2O5S

Molecular Weight

572.34

References & Citations

[1]Iverson C, et al. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69 (17) :6839-47.