(rac) -Talazoparib

(rac) -Talazoparib ((rac) -BMN-673) (Compound 47) is the orally active inhibitor for PARP1/2 with Ki of 1.2 nM and 0.87 nM. (rac) -Talazoparib inhibits cellular PARylation with an EC50 of 2.51 nM. (rac) -Talazoparib causes the accumulation of DNA damage, inhibits proliferation of BRCA1/2-mutated MX-1 cell and Capan-1 cell with IC50 of 0.3 nM and 5 nM. (rac) -Talazoparib exhibits antitumor efficacy in mouse models[1].