Diltiazem-d6 (hydrochloride)

Diltiazem-d6 (hydrochloride) (CRD-401-d6 (hydrochloride) ) is deuterium labeled Diltiazem (hydrochloride) . Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist) .

Product Specifications

CAS Number

[1309283-34-8]

Product Name Alternative

CRD-401-d6 (hydrochloride)

UNSPSC

12352005

Target

Calcium Channel; Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease; Cancer

Smiles

CC(O[C@@H]1[C@@](C2=CC=C(C=C2)OC)([H])SC3=CC=CC=C3N(C1=O)CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.Cl

Molecular Formula

C22H21D6ClN2O4S

Molecular Weight

457.02

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl) . Nihon Yakurigaku Zasshi. 1979 Mar;75 (2) :99-106.|[3]Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29 (1) :31-40.|[4]Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36 (17) :2735-40.|[5]van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218 (2) :459-63.|[6]Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273 (42) :27205-12.