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MPEP (Hydrochloride) (Standard)

MPEP (Hydrochloride) (Standard) is the analytical standard of MPEP (Hydrochloride) . This product is intended for research and analytical applications. MPEP Hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP Hydrochloride has anxiolytic-or antidepressant-like effects[1][2]. MPEP (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

219911-35-0

UNSPSC

12352100

Target

MGluR; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC1=NC(C#CC2=CC=CC=C2)=CC=C1.[H]Cl

Molecular Formula

C14H12ClN

Molecular Weight

229.70

References & Citations

[1]F Gasparini, et al. 2-Methyl-6- (phenylethynyl) -pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38 (10) :1493-503.|[2]E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132 (7) :1423-30.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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