Osunprotafib (hydrochloride)
Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active and selective active site PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM) inhibitor. Osunprotafib hydrochloride has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib hydrochloride increases the sensitivity of human cancer cell lines to IFNγ. Osunprotafib hydrochloride generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction[1][2][3][4].
Product Specifications
CAS Number
2986745-48-4
Product Name Alternative
ABBV-CLS-484 (hydrochloride)
UNSPSC
12352005
Target
JAK; Phosphatase; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(CN1C2=C(C=C3CC[C@@H](NCCC(C)C)CC3=C2F)O)NS1(=O)=O.Cl
Molecular Formula
C17H25ClFN3O4S
Molecular Weight
421.91
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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