CP-17
CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research[1].
Product Specifications
CAS Number
[1111233-06-7]
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC(Cl)=CC=C1C)NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2N4CCCC4
Molecular Formula
C25H25ClN4O2
Molecular Weight
448.94
References & Citations
[1]Chen J, et al. Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells. Cell Commun Signal. 2020 Apr 3;18 (1) :55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDH2
Curated Selection
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