Zilebesiran (sodium)

Zilebesiran sodium is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of syste

Product Specifications

CAS Number

[2380166-34-5]

Product Name Alternative

AD-85481 sodium; ALN-AGT sodium

UNSPSC

12352208

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

[Zilebesiran(sodium)]

Molecular Formula

C532H678F7N177Na43O321P43S6

Molecular Weight

16389 (free acid)

References & Citations

[1]Desai AS, Webb DJ, Taubel J, et al. Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023;389 (3) :228-238. doi:10.1056/NEJMoa2208391|[2]Bakris GL, Saxena M, Gupta A, et al. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024;331 (9) :740-749.