Zilebesiran
Zilebesiran is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of systemic blood pressure.
Product Specifications
CAS Number
2380166-33-4
Product Name Alternative
AD-85481; ALN-AGT
UNSPSC
12352100
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
[Zilebesiran]
Molecular Formula
C532H721F7N177O321P43S6
Molecular Weight
16389
References & Citations
[1]Bakris GL, Saxena M, Gupta A, et al. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024;331 (9) :740-749. |[2]Desai AS, Karns AD, Badariene J, et al. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial. JAMA. 2025;334 (1) :46-55.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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