Zilebesiran

Zilebesiran is a siRNA that reduce hepatic angiotensinogen levels through RNA interference. it is used for the study of mild to moderate Hypertension. Angiotensinogen is the predominant precursor of angiotensin peptides and a key regulator of systemic blood pressure.

Product Specifications

CAS Number

[2380166-33-4]

Product Name Alternative

AD-85481; ALN-AGT

UNSPSC

12352100

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

[Zilebesiran]

Molecular Formula

C532H721F7N177O321P43S6

Molecular Weight

16389

References & Citations

[1]Bakris GL, Saxena M, Gupta A, et al. RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024;331 (9) :740-749. |[2]Desai AS, Karns AD, Badariene J, et al. Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial. JAMA. 2025;334 (1) :46-55.