Idazoxan (hydrochloride) (Standard)

Idazoxan (hydrochloride) (Standard) is the analytical standard of Idazoxan (hydrochloride) . This product is intended for research and analytical applications. Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs) . Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2].

Product Specifications

CAS Number

[79944-56-2]

UNSPSC

12352100

Target

Adrenergic Receptor; Imidazoline Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Smiles

[H]Cl.C1(C2OC3=CC=CC=C3OC2)=NCCN1

Molecular Formula

C11H13ClN2O2

Molecular Weight

240.69

References & Citations

[1]Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003) .|[2]Bousquet P, et al. Participation of imidazoline receptors and alpha (2-) -adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8.