Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

KT-474 (hydrochloride)

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups[1][2][3].

Product Specifications

CAS Number

2751703-31-6

Product Name Alternative

KYM-001 (hydrochloride) ; PROTAC IRAK4 degrader-7 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; IRAK; PROTACs

Related Pathways

Apoptosis; Immunology/Inflammation; PROTAC

Field of Research

Cancer

Purity

98.0

Smiles

O=C1N(C(CCC2=O)C(N2)=O)C3=CC=CC(C#CCOC(CC4)CCN4C[C@H]5CC[C@@](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@@H](CO9)C[C@@H]9C8)C=C%10)N%10N=C7)=O)([H])CC5)=C3N1C.Cl

Molecular Formula

C44H50ClF2N11O6

Molecular Weight

902.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Nello Mainolfi, et al. Irak degraders and uses thereof. Patent WO2020113233A1.|[2]Ackerman L, et al. IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial. Nat Med. 2023 Dec;29 (12) :3127-3136.|[3]Joseph F. Kelleher, et al. Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition. Cancer Res (2019) 79 (13_Supplement) : LB-272.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

10,11-Dihydro-5H-dibenzo[b,f]azepine
TRC-D448870-10G 10 g

10,11-Dihydro-5H-dibenzo[b,f]azepine

Sign In for Pricing
View Details
Brms1l Mouse Gene Knockout Kit (CRISPR)
KN502272 1 Kit

Brms1l Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Flavine Adenine Dinucleotide-13C5 Ammonium Salt
TRC-F371502-5MG 5 mg

Flavine Adenine Dinucleotide-13C5 Ammonium Salt

Sign In for Pricing
View Details
Tissue Total RNA, Thyroid gland
CR562130 5 µg

Tissue Total RNA, Thyroid gland

Sign In for Pricing
View Details
Cyclo(-Gly-Phe)
TRC-C989715-250MG 250 mg

Cyclo(-Gly-Phe)

Sign In for Pricing
View Details
Ethyl 3-cyclopropyl-3-oxopropanoate
TRC-E926328-50G 50 g

Ethyl 3-cyclopropyl-3-oxopropanoate

Sign In for Pricing
View Details