KT-474 (hydrochloride)
KT-474 (KYM-001; PROTAC IRAK4 degrader-7) hydrochloride is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups[1][2][3].
Product Specifications
CAS Number
2751703-31-6
Product Name Alternative
KYM-001 (hydrochloride) ; PROTAC IRAK4 degrader-7 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; IRAK; PROTACs
Related Pathways
Apoptosis; Immunology/Inflammation; PROTAC
Field of Research
Cancer
Purity
98.0
Smiles
Molecular Formula
C44H50ClF2N11O6
Molecular Weight
902.39
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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