SEP-4199
SEP-4199 is a nonracemic 85:15 ratio of Aramisulpride and Esamisulpride (HY-126068). SEP-4199 exhibits significant differences in relative potency at two different receptors (5-HT7R and D2R) compared to the racemate. SEP-4199 exhibits antidepressant effects[1].
Product Specifications
CAS Number
2974362-88-2
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CCN1[C@@H](CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1.CCN3[C@H](CNC(C4=CC(S(=O)(CC)=O)=C(N)C=C4OC)=O)CCC3
Molecular Formula
C17H27N3O4S
Molecular Weight
369.48
References & Citations
[1]Hopkins SC, et al. Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. Clin Pharmacol Ther. 2021 Sep;110 (3) :808-815.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; D2 Receptor
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