Tetrahydrofolic acid-13C5

Tetrahydrofolic acid-13C5 (L-5,6,7,8-Tetrahydrofolic acid-13C5) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1].

Product Specifications

Product Name Alternative

L-5,6,7,8-Tetrahydrofolic acid-13C5; L-Tetrahydrofolic acid-13C5

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

NC(NC1=C2NC(CNC3=CC=C(C(N[13C@@H]([13C][13C][13C](O)=O)C)=O)C=C3)CN1)=NC2=O.C[13C](O)=O

Molecular Formula

C16 13C5H25N7O6

Molecular Weight

476.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Clara B García-Calderón, et al. Genotoxicity of Tetrahydrofolic Acid to Hematopoietic Stem and Progenitor Cells. Cell Death Differ. 2018 Nov;25 (11) :1967-1979.