(6S) -Tetrahydrofolic acid
(6S) -Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S) -Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein[1].
Product Specifications
CAS Number
[71963-69-4]
Product Name Alternative
(6S) -5,6,7,8-Tetrahydrofolic acid
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC(N)=N1)NC[C@@H](N2)CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
Molecular Formula
C19H23N7O6
Molecular Weight
445.43
References & Citations
[1]Steven W. Bailey, et al. Synthesis of Tetrahydropteridine C6-Stereoisomers, Including N6-Formyl- (68) -tetrahydrofolic Acid. The Journal of Organic Chemistry, 57 (16), 4470-4477.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Curated Selection
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