Tetrahydrofolic acid

Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1].

Product Specifications

CAS Number

[135-16-0]

Product Name Alternative

L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

97.07

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

NC(NC1=C2NC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)CN1)=NC2=O

Molecular Formula

C19H23N7O6

Molecular Weight

445.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Clara B García-Calderón, et al. Genotoxicity of Tetrahydrofolic Acid to Hematopoietic Stem and Progenitor Cells. Cell Death Differ. 2018 Nov;25 (11) :1967-1979.