H3R antagonist 5
H3R antagonist 5 (Compound 1b) is a selective histamine H3 receptor inverse agonist with a IC50 of 0.54 nM and the ability to cross the blood-brain barrier. H3R antagonist 5 can be used in central nervous system-related research[1].
Product Specifications
CAS Number
879368-27-1
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=CC=C2C(C(O[C@@]23CC[C@@H](C(N(CCN4CCCCC4)C)=O)CC3)=O)=C1
Molecular Formula
C23H32N2O4
Molecular Weight
400.51
References & Citations
[1]Jitsuoka M, et al. Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett. 2008 Sep 15;18 (18) :5101-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; H2 Receptor; H3 Receptor; H4 Receptor
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