H3R antagonist 5
H3R antagonist 5 (Compound 1b) is a selective histamine H3 receptor inverse agonist with a IC50 of 0.54 nM and the ability to cross the blood-brain barrier. H3R antagonist 5 can be used in central nervous system-related research[1].
Product Specifications
CAS Number
879368-27-1
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC1=CC=C2C(C(O[C@@]23CC[C@@H](C(N(CCN4CCCCC4)C)=O)CC3)=O)=C1
Molecular Formula
C23H32N2O4
Molecular Weight
400.51
References & Citations
[1]Jitsuoka M, et al. Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists. Bioorg Med Chem Lett. 2008 Sep 15;18 (18) :5101-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; H2 Receptor; H3 Receptor; H4 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1091618 Inquire
Recombinant Porphyra purpurea Uncharacterized protein ORF621, partial
Sign In for Pricing
View Details 
A04553-1-PE 100 µg/Vial
Anti-Cenpe Antibody Picoband®, PE Conjugate
Sign In for Pricing
View Details K1832004 1.0 µg DNA
RNASE10 sgRNA CRISPR Lentivector (Human) (Target 3)
Sign In for Pricing
View Details 
MBS2143026-01 0.1 mL
FITC-Linked Monoclonal Antibody to Cystatin C (Cys-C)
Sign In for Pricing
View Details