AF-353 (Standard)

AF-353 (Standard) is the analytical standard of AF-353. This product is intended for research and analytical applications. AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].

Product Specifications

CAS Number

[865305-30-2]

UNSPSC

12352100

Target

P2X Receptor; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cancer

Smiles

CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1

Molecular Formula

C14H17IN4O2

Molecular Weight

400.21

References & Citations

[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160 (6) :1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110 (8 Pt B) :E409-414.