Itanapraced (Standard)

Itanapraced (Standard) is the analytical standard of Itanapraced. This product is intended for research and analytical applications. Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD) . Itanapraced can be used for the research of Alzheimer's disease[1][2].

Product Specifications

CAS Number

[749269-83-8]

UNSPSC

12352100

Target

Apoptosis; Reference Standards; γ-secretase

Related Pathways

Apoptosis; Neuronal Signaling; Others; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O

Molecular Formula

C16H11Cl2FO2

Molecular Weight

325.16

References & Citations

[1]Imbimbo BP, et al. 1- (3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl) -cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323 (3) :822-830.|[2]Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.