Redafamdastat (Standard)
Redafamdastat (Standard) is the analytical standard of Redafamdastat. This product is intended for research and analytical applications. Redafamdastat (PF-04457845) is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for hFAAH and rFAAH, respectively.
Product Specifications
CAS Number
1020315-31-4
UNSPSC
12352100
Target
Autophagy; FAAH; Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(NC1=NN=CC=C1)N(CC/2)CCC2=C\C3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3
Molecular Formula
C23H20F3N5O2
Molecular Weight
455.43
References & Citations
[1]Johnson DS, et al. Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2 (2) :91-96.|[2]Ahn K, et al. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J Pharmacol Exp Ther. 2011 Jul;338 (1) :114-24.|[3]Buntyn RW, et al. Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats. Int J Toxicol. 2017 Jan 1:1091581817725272.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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