LX2932
LX2932 is an orally active LX2931 analogue and S1P/S1PR signaling axis modulator. LX2932 yields a dose-dependent decrease in circulating lymphocyte numbers. LX2932 improves collagen-induced arthritis[1][2].
Product Specifications
CAS Number
1055027-48-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Derivative; LPL Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Inflammation/Immunology
Smiles
[C@@H]([C@@H]([C@@H](CO)O)O)(O)C=1NC(=NC1)C=2C=CON2
Molecular Formula
C10H13N3O5
Molecular Weight
255.23
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bagdanoff JT, et al. Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E) -1- (4- ((1R,2S,3R) -1,2,3,4-tetrahydroxybutyl) -1H-imidazol-2-yl) ethanone oxime (LX2931) and (1R,2S,3R) -1- (2- (isoxazol-3-yl) -1H-imidazol-4-yl) butane-1,2,3,4-tetraol (LX2932) . J Med Chem. 2010 Dec 23;53 (24) :8650-62. |[2]Gao Y, et al. Rheumatoid arthritis: pathogenesis and therapeutic advances. MedComm (2020) . 2024 Mar 10;5 (3) :e509.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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