MK 1256
MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC50 of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times) . MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis[1].
Product Specifications
CAS Number
919109-76-5
UNSPSC
12352005
Target
Cathepsin
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C([C@H]1[C@H](C2=NN(CC(F)(F)F)C=C2C3=CC=C(S(=O)(C)=O)C=C3)CCC(Cl)(Cl)C1)NC4(C#N)CC4
Molecular Formula
C23H23Cl2F3N4O3S
Molecular Weight
563.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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