GSK-163090 (dihydrochloride)

GSK-163090 dihydrochloride is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4, 8.5 and 9.7, respectively. GSK-163090 dihydrochloride inhibits the functional activity of serotonin reuptake transporter (SerT) with a pKi value of 6.1. GSK-163090 dihydrochloride has antidepressant and anxiolytic activities[1].

Product Specifications

CAS Number

[844903-52-2]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1NCCN1C2=CC=CC(CCN3CCN(C4=C5C=CC(C)=NC5=CC=C4)CC3)=C2.Cl.Cl

Molecular Formula

C25H31Cl2N5O

Molecular Weight

488.45

References & Citations

[1]Leslie CP, et al. Discovery of 1- (3-{2-[4- (2-methyl-5-quinolinyl) -1-piperazinyl]ethyl}phenyl) -2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. J Med Chem. 2010 Dec 9;53 (23) :8228-8240.