KLYP961
KLYP961 is a selective and orally active dual inhibitor of inducible and neuronal NO synthase (IC50 = 50-400 nM) . KLYP961 can inhibit endotoxin-evoked plasma nitrates increases and attenuate pain behaviors in a mouse formalin model. KLYP961 can attenuate carrageenin-induced edema and inflammatory hyperalgesia and writhing response elicited by Phenylbenzoquinone (HY-W275039) . KLYP961 can be used for the research of neurological disease[1].
Product Specifications
CAS Number
[1125746-49-7]
UNSPSC
12352005
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
O=C1C=C(CN2C3=C(N=C2C4CCC4)N=CC=N3)C5=C(N1)C(F)=C(F)C=C5
Molecular Formula
C19H15F2N5O
Molecular Weight
367.35
References & Citations
[1]Symons KT, et al. Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases. J Pharmacol Exp Ther. 2011 Feb;336 (2) :468-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; nNOS
Curated Selection
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