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SB 271046 (Hydrochloride) (Standard)

SB 271046 (Hydrochloride) (Standard) is the analytical standard of SB 271046 (Hydrochloride) . This product is intended for research and analytical applications. SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM) [1].

Product Specifications

CAS Number

209481-24-3

UNSPSC

12352100

Target

5-HT Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

ClC1=CC2=C(C=C1)SC(S(=O)(NC3=CC=C(C(N4CCNCC4)=C3)OC)=O)=C2C.[H]Cl

Molecular Formula

C20H23Cl2N3O3S2

Molecular Weight

488.45

References & Citations

[1]Routledge C, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT (6) receptor antagonist. Br J Pharmacol. 2000;130 (7) :1606-1612.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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