SAM-315

SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with Ki and IC50 of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain[1].

Product Specifications

CAS Number

[744218-85-7]

Product Name Alternative

WAY-255315

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=S(C1=NNC2=C1C=C(N3CCNCC3)C=C2)(C4=CC=CC5=C4C=CC=C5)=O

Molecular Formula

C21H20N4O2S

Molecular Weight

392.47

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists J. Med. Chem., Article ASAP DOI: 10.1021/jm1007825 Publication Date (Web) : October 8, 2010|[2]Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists. J Med Chem. 2010 Nov 11;53 (21) :7639-46.