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Pinacidil (monohydrate) (Standard)

Pinacidil (monohydrate) (Standard) is the analytical standard of Pinacidil (monohydrate) . This product is intended for research and analytical applications. Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil monohydrate enhances K+-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases[1][2].

Product Specifications

CAS Number

85371-64-8

UNSPSC

12352100

Target

Potassium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Smiles

[H]O[H].CC(C)(C)C(N/C(NC#N)=N/C1=CC=NC=C1)C

Molecular Formula

C13H21N5O

Molecular Weight

263.34

References & Citations

[1]Hamilton TC, et al., Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20 (1) :1-9. |[2]Jung-Ae Kim, et al., Activation of Na+, K+, Cl−-Cotransport Mediates Intracellular Ca2+ Increase and Apoptosis Induced by Pinacidil in HepG2 Human Hepatoblastoma Cells, Biochemical and Biophysical Research Communications, Volume 281, Issue 2, 2001, Pages 511-519, ISSN 0006-291X, |[3]Weston, A.H., et al., In Vitro Studies on the Mode of Action of Pinacidil. Drugs 36 (Suppl 7), 10–28 (1988) . |[4]Ko Zushida, et al ., Effect of diabetes on pinacidil-induced antinociception in mice, European Journal of Pharmacology, Volume 453, Issues 2–3, 2002, Pages 209-215, ISSN 0014-2999.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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