Verapamil-d3

Verapamil-d3 ((±) -Verapamil-d3) is deuterium labeled Verapamil. Verapamil ((±) -Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

Product Specifications

CAS Number

[152561-91-6]

Product Name Alternative

(±) -Verapamil-d3; CP-16533-1-d3

UNSPSC

12352005

Target

Calcium Channel; Cytochrome P450; Isotope-Labeled Compounds; P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cancer; Cardiovascular Disease

Smiles

COC(C=C1CCN(C([2H])([2H])[2H])CCCC(C#N)(C2=CC(OC)=C(C=C2)OC)C(C)C)=C(C=C1)OC

Molecular Formula

C27H35D3N2O4

Molecular Weight

457.62

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25 (3) :743-746.|[3]Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.|[4]Rehnqvist N, et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) . Eur Heart J. 1996 Jan;17 (1) :76-81.|[5]Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35 (5) :93.|[6]Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8 (8) :e71567.