CDK6/PIM1-IN-1 (hydrochloride)

CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 (IC50=3.6 nM) . CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].

Product Specifications

CAS Number

[2677026-15-0]

UNSPSC

12352005

Target

Apoptosis; CDK; Pim

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling

Field of Research

Cancer

Purity

99.38

Smiles

FC1=CN=C(NC2=NC=C(N3CCNCC3)C=C2)N=C1C4=CC=C5N=CC(N(CC)CC)=NC5=C4.Cl

Molecular Formula

C25H29ClFN9

Molecular Weight

510.01

References & Citations

[1]Kai Yuan, et al. Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2022 Jan 13;65 (1) :857-875.