Dapivirine (Standard)

Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI) . Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].

Product Specifications

CAS Number

[244767-67-7]

UNSPSC

12352100

Target

Apoptosis; Autophagy; HIV; Reference Standards; Reverse Transcriptase

Related Pathways

Anti-infection; Apoptosis; Autophagy; Others

Field of Research

Infection

Smiles

CC1=CC(C)=CC(C)=C1NC2=CC=NC(NC3=CC=C(C#N)C=C3)=N2

Molecular Formula

C20H19N5

Molecular Weight

329.41

References & Citations

[1]Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9 (1) :117-128.|[2]Bríd Devlin, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8.|[3]Yven Van Herrewege, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48 (1) :337-9.|[4]Michael E Halwes, et al. Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci. 2016 Oct 10;93:410-8.