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BMS-191095 (hydrochloride)

BMS-191095 hydrochloride is a mitochondrial KATP channel opener. BMS-191095 hydrochloride can protect the myocardium without causing vasodilation or affecting electrophysiology, by prolonging the contraction time during ischemia, improving contractile function after reperfusion, and reducing lactate dehydrogenase (LDHM) release, thereby exerting its cardioprotective effects[1].

Product Specifications

CAS Number

166095-95-0

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Lactate Dehydrogenase; Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

CC(O1)(C)[C@H](O)[C@@H](N(CC2=NC=CN2)C3=CC=C(Cl)C=C3)C4=C1C=CC(C#N)=C4.Cl

Molecular Formula

C22H22Cl2N4O2

Molecular Weight

445.34

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Grover GJ, et al. Pharmacologic profile of the selective mitochondrial-K (ATP) opener BMS-191095 for treatment of acute myocardial ischemia. Cardiovasc Drug Rev. 2002 Summer;20 (2) :121-36.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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