Olprinone (Standard)

Olprinone (Standard) is the analytical standard of Olprinone. This product is intended for research and analytical applications. Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[106730-54-5]

UNSPSC

12352100

Target

Phosphodiesterase (PDE) ; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Smiles

CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3

Molecular Formula

C14H10N4O

Molecular Weight

250.26

References & Citations

[1]Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350 (3) :284-293.|[2]Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650 (2-3) :612-620.