Olprinone (Standard)
Olprinone (Standard) is the analytical standard of Olprinone. This product is intended for research and analytical applications. Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].
Product Specifications
CAS Number
106730-54-5
UNSPSC
12352100
Target
Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3
Molecular Formula
C14H10N4O
Molecular Weight
250.26
References & Citations
[1]Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350 (3) :284-293.|[2]Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650 (2-3) :612-620.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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