Ditolylguanidine (Standard)
Ditolylguanidine (Standard) is the analytical standard of Ditolylguanidine. This product is intended for research and analytical applications. Ditolylguanidine (1,3-Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor) with Ki values of 69 and 21 nM for σ1 and σ2 receptors, respectively. Ditolylguanidine effectively inhibits the growth of small cell lung cancer cells. Ditolylguanidine can be used for the research of lung cancer[1][2][3][4].
Product Specifications
CAS Number
97-39-2
UNSPSC
12352100
Target
Reference Standards; Sigma Receptor
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CC1=C(NC(NC2=CC=CC=C2C)=N)C=CC=C1
Molecular Formula
C15H17N3
Molecular Weight
239.32
References & Citations
[1]Shimizu I, et al. Effects of (+) -pentazocine and 1,3-di-o-tolylguanidine (DTG), sigma (sigma) ligands, on micturition in anaesthetized rats. Br J Pharmacol. 2000 Oct;131 (3) :610-6.|[2]John CS, et al. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci. 1995;56 (26) :2385-92.|[3]Moody TW, et al. Sigma ligands inhibit the growth of small cell lung cancer cells. Life Sci. 2000 Apr 7;66 (20) :1979-86.|[4]Moison D, et al. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology. 2003 Dec;45 (7) :945-53.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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