BI-9466
BI-9466 (Compound 2) is a nuclear receptor-binding SET domain 3 (NSD3) -PWWP1 domain antagonist with a Kd of 144 µM. BI-9466 is a negative control compound of BI-9321 (HY-114208) . BI-9466 has no inhibitory activity against NSD3-PWWP1 domain by introduction of a much basic nitrogen heterocycle at the 5-position of BI-9321[1].
Product Specifications
CAS Number
[2538293-52-4]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
CN1C=NC(C2=C(C)C=C(CN)C=C2C)=C1C3=CN=CN3C
Molecular Formula
C17H21N5
Molecular Weight
295.38
References & Citations
[1]Böttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15 (8) :822-829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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