27-O-Demethylrapamycin

27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum[1].

Product Specifications

CAS Number

[141392-23-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@](CCCC2)([H])C(O[C@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@H](C[C@@]3([H])O[C@@](C1=O)([C@@H](CC3)C)O)OC)\C)C)C)=O)O)O)\C)C)=O)([H])[C@H](C)C[C@H]4C[C@H]([C@@H](CC4)O)OC)=O

Molecular Formula

C50H77NO13

Molecular Weight

900.15

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wong GK, et al. Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin. J Antibiot (Tokyo) . 1998 May;51 (5) :487-91.