Clorgyline hydrochloride (Standard)

Clorgyline hydrochloride (Standard) is the analytical standard of Clorgyline hydrochloride. This product is intended for research and analytical applications. Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A) . Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3].

Product Specifications

CAS Number

[17780-75-5]

UNSPSC

12352100

Target

Monoamine Oxidase; Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Metabolic Disease

Smiles

C#CCN(CCCOC1=CC=C(Cl)C=C1Cl)C.[H]Cl

Molecular Formula

C13H16Cl3NO

Molecular Weight

308.63

References & Citations

[1]Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline) . Journal of neural transmission. Supplementum 52: 39-48.|[2]Guillem K, et al. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats[J]. Eur J Neurosci. 2006 Dec;24 (12) :3532-40. |[3]Tyce GM, et al. Conjugated dopamine in superfusates of slices of rat striatum[J]. J Neurochem. 1982 Nov;39 (5) :1333-9.