Lixivaptan (Standard)
Lixivaptan (Standard) is the analytical standard of Lixivaptan. This product is intended for research and analytical applications. Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.
Product Specifications
CAS Number
168079-32-1
UNSPSC
12352100
Target
Reference Standards; Vasopressin Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease; Endocrinology
Smiles
O=C(C1=C(Cl)C=C(NC(C2=CC(F)=CC=C2C)=O)C=C1)N(C3)C4=CC=CC=C4CN5C3=CC=C5
Molecular Formula
C27H21ClFN3O2
Molecular Weight
473.93
References & Citations
[1]Albright JD, et al. 5-Fluoro-2-methyl-N-[4- (5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10 (11H) -ylcarbonyl) -3-chlorophenyl]benzamide (VPA-985) : an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem. 1998 Jul 2;41 (14) :2442-4.|[2]Ghali JK, et al. Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs. 2010 Nov;13 (11) :782-92.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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