Lixivaptan (Standard)

Lixivaptan (Standard) is the analytical standard of Lixivaptan. This product is intended for research and analytical applications. Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively.

Product Specifications

CAS Number

[168079-32-1]

UNSPSC

12352100

Target

Reference Standards; Vasopressin Receptor

Related Pathways

GPCR/G Protein; Others

Field of Research

Cardiovascular Disease; Endocrinology

Smiles

O=C(C1=C(Cl)C=C(NC(C2=CC(F)=CC=C2C)=O)C=C1)N(C3)C4=CC=CC=C4CN5C3=CC=C5

Molecular Formula

C27H21ClFN3O2

Molecular Weight

473.93

References & Citations

[1]Albright JD, et al. 5-Fluoro-2-methyl-N-[4- (5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10 (11H) -ylcarbonyl) -3-chlorophenyl]benzamide (VPA-985) : an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem. 1998 Jul 2;41 (14) :2442-4.|[2]Ghali JK, et al. Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyponatremia. IDrugs. 2010 Nov;13 (11) :782-92.