STF-1084
STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (Ki = 33 nM) . STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity[1].
Product Specifications
CAS Number
[2298390-71-1]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H318, H332, H335
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.7
Smiles
OP(O)(CCC1CCN(C2=C3C=C(OC)C(OC)=CC3=NC=N2)CC1)=O
Molecular Formula
C17H24N3O5P
Molecular Weight
381.36
Precautions
H302, H312, H315, H318, H332, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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