Cinaciguat (hydrochloride) (Standard)

Cinaciguat (hydrochloride) (Standard) is the analytical standard of Cinaciguat (hydrochloride) . This product is intended for research and analytical applications. Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.

Product Specifications

CAS Number

[646995-35-9]

UNSPSC

12352100

Target

Guanylate Cyclase; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cardiovascular Disease

Smiles

OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC(C=CC=C2)=C2OCC(C=C3)=CC=C3CCC4=CC=CC=C4)=O.[H]Cl

Molecular Formula

C36H40ClNO5

Molecular Weight

602.16

References & Citations

[1]Roy B, et al. Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br J Pharmacol. 2008 Apr;153 (7) :1495-504.|[2]Thoonen R, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015 Oct 7;6:8482.