Begacestat (Standard)
Begacestat (Standard) is the analytical standard of Begacestat. This product is intended for research and analytical applications. Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].
Product Specifications
CAS Number
769169-27-9
UNSPSC
12352100
Target
Reference Standards; γ-secretase
Related Pathways
Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
FC(F)(F)C([C@H](NS(=O)(C1=CC=C(Cl)S1)=O)CO)C(F)(F)F
Molecular Formula
C9H8ClF6NO3S2
Molecular Weight
391.74
References & Citations
[1]Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem. 2008 Dec 11;51 (23) :7348-51.|[2]Martone RL, et al. Begacestat (GSI-953) : a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331 (2) :598-608.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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