Bexarotene-13C6

Bexarotene-13C6 (LGD1069-13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) [1][2][3]. Bexarotene can be used for the research of cutaneous T-cell lymphoma.

Product Specifications

Product Name Alternative

LGD1069-13C6

UNSPSC

12352005

Target

Autophagy; Isotope-Labeled Compounds; RAR/RXR

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1(C2=C(C(C)(CC1)C)C=C(C(C([13C]3=[13C][13C]=[13C]([13C]=[13C]3)C(O)=O)=C)=C2)C)C

Molecular Formula

C18 13C6H24O2

Molecular Weight

350.40

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Nathalia Rodrigues de Almeida, et al. A review of the molecular design and biological activities of RXR agonists. Med Res Rev. 2019 Jul;39 (4) :1372-1397.|[3]Danyang Shen, et al. Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer. Onco Targets Ther. 2019 Sep 24;12:7877-7886.|[4]Y Wang, et al. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 2006 Mar 2;25 (9) :1320-9.