ZA10

ZA10 is a selective TRPM2 channel inhibitor, with an IC50 value of 8.1 μM. ZA10 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA10 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA10 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases[1].

Product Specifications

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC2=CC=CC=C2O1)C3=C(C)N=C4N(CCN(CC)CC)C5=CC=CC=C5N43

Molecular Formula

C25H26N4O2

Molecular Weight

414.50

References & Citations

[1]Zhao S, et al. Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specfic inhibitors. Eur J Med Chem. 2021 Dec 5;225:113750.