ZA18
ZA18 is a selective TRPM2 channel inhibitor, with an IC50 value of 6.2 μM. ZA18 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA18 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA18 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases[1].
Product Specifications
CAS Number
2696407-32-4
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)C3=C(C)N=C4N(CCN(CC)CC)C5=CC=CC=C5N43
Molecular Formula
C29H30N4O
Molecular Weight
450.57
References & Citations
[1]Zhao S, et al. Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specfic inhibitors. Eur J Med Chem. 2021 Dec 5;225:113750.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM8
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