(2S,3S,11bR) -Dihydrotetrabenazine
(2S,3S,11bR) -Dihydrotetrabenazine ((2S,3S,11bR) -DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR) -Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR) -Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders[1].
Product Specifications
CAS Number
862377-27-3
Product Name Alternative
(2S,3S,11bR) -DHTBZ
UNSPSC
12352005
Target
Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
COC1=C(OC)C=C2CCN(C[C@@H]([C@H](C3)O)CC(C)C)[C@@]3([H])C2=C1
Molecular Formula
C19H29NO3
Molecular Weight
319.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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