(2S,3S,11bR) -Dihydrotetrabenazine

(2S,3S,11bR) -Dihydrotetrabenazine ((2S,3S,11bR) -DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR) -Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR) -Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders[1].

Product Specifications

CAS Number

[862377-27-3]

Product Name Alternative

(2S,3S,11bR) -DHTBZ

UNSPSC

12352005

Target

Monoamine Transporter

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

COC1=C(OC)C=C2CCN(C[C@@H]([C@H](C3)O)CC(C)C)[C@@]3([H])C2=C1

Molecular Formula

C19H29NO3

Molecular Weight

319.44

References & Citations

[1]Yao Z, et al. Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors. Eur J Med Chem. 2011 May;46 (5) :1841-8.