MPT0G413
MPT0G413 (Compound 6) is a potent, selective, orally active and brain-penetrant HDAC6 inhibitor with an IC50 of 3.92 nM. MPT0G413 decreases not only the level of phosphorylation of tau proteins but also the aggregation of tau proteins. MPT0G413 can ameliorate the impaired learning and memory. MPT0G413 can be used for the research of neurological disease, such as Alzheimer's disease[1].
Product Specifications
CAS Number
[2241643-23-0]
UNSPSC
12352005
Target
HDAC; Tau Protein
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NO)C1=CC=C(CN2C=CC3=C2C=CC(C(C4=CC=C(OC)C=C4)=O)=C3)C=C1
Molecular Formula
C24H20N2O4
Molecular Weight
400.43
References & Citations
[1]Lee HY, et al. 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes. J Med Chem. 2018 Aug 23;61 (16) :7087-7102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
Curated Selection
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