BPR-890

BPR-890 is a potent agonist of CB1. BPR-890 exhibits excellent CB2/1 selectivity and has in vivo efficacy in diet-induced obese mouse model[1].

Product Specifications

CAS Number

[1170700-86-3]

UNSPSC

12352005

Target

Cannabinoid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

S=C1N=C(C2=NN(C3=CC=C(Cl)C=C3Cl)C(C4=CC=C(Cl)C=C4)=C2CC)N(C)C1(C)C

Molecular Formula

C23H21Cl3N4S

Molecular Weight

491.86

References & Citations

[1]Wu, C. H., et al., (2009) . Discovery of 2-[5- (4-chloro-phenyl) -1- (2,4-dichloro-phenyl) -4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. Journal of medicinal chemistry, 52 (14), 4496-4510.